HOKE NR Formula Ingredient Analysis: What are the functions of NR, Ca-AKG, PQQ, and Ergothioneine respectively?

When looking at NAD+ products, you can't just look at one ingredient.

Whether a single ingredient is good or not is certainly important.
Whether the formula has a logic to it is also very important.

HOKE's approach is to use NR as the core, then combine it with ingredients related to energy metabolism, mitochondrial nutritional support, and antioxidant nutritional support to form a compound formula.

Each two capsules of HOKE contain 600mg of Boncata® NR, 100mg of Ca-AKG, 20mg of PQQ, 100mg of magnesium glycinate, 30mg of Varginsen® rare ginsenosides, 70mg of Cocrysta™ co-crystallized curcumin, and 50mg of ergothioneine.

First Layer: Boncata® NR, focused on NAD+ precursor support

NR, full name Nicotinamide Riboside, is one of the common ingredients in NAD+ precursors.

NIH data states that niacin-related nutrients include forms such as niacin, nicotinamide, and nicotinamide riboside, which human tissues convert into NAD; NAD participates in energy metabolism, redox reactions, and cellular functions.

NR as the core of NAD+ precursor nutritional support.

Second Layer: Ca-AKG and Magnesium Glycinate, focused on energy metabolism support

Ca-AKG and magnesium glycinate are included in the HOKE formula to complete the energy metabolism-related formula logic.

The nutritional basis for magnesium is relatively clear. NIH magnesium data states that magnesium is a cofactor for over 300 enzyme systems and is involved in energy production, oxidative phosphorylation, and glycolysis.

Supports energy metabolism related nutritional needs.
Supports adults' daily mineral supplementation approach.
As an energy homeostasis supporting ingredient in a compound formula.

Third Layer: PQQ and Ergothioneine, focused on mitochondrial and antioxidant nutritional support

PQQ and ergothioneine are considered in terms of mitochondrial nutritional support and antioxidant nutritional support. PQQ can serve as an ingredient related to mitochondrial nutritional support.

Ergothioneine can serve as an ingredient related to antioxidant nutritional support.

Fourth Layer: Co-crystallized Curcumin and Rare Ginsenosides, supplementing antioxidant and daily health management dimensions

The HOKE formula also includes Cocrysta™ co-crystallized curcumin and Varginsen® rare ginsenosides.

Turmeric and curcumin are common botanical nutrients. NCCIH states that turmeric and curcumin are often studied as dietary supplements, but evidence for health conditions is still limited, and some groups need to be aware of safety.

Co-crystallized curcumin is used to supplement the antioxidant nutritional support dimension.
Rare ginsenosides are used to supplement the daily health management dimension for adults.

The Core Logic of HOKE's Formula

HOKE's formula can be summarized in three sentences:

NR: Focused on NAD+ precursor support.
Ca-AKG + Magnesium Glycinate: Focused on energy metabolism nutritional support.
PQQ + Ergothioneine + Curcumin + Ginsenosides: Focused on antioxidant nutritional support and health management.

This is what distinguishes it from single NMN products.

FAQ

What is HOKE's core ingredient?

HOKE's core ingredient is Boncata® NR, with 600mg per two capsules.

Why did HOKE add magnesium glycinate?

Magnesium is involved in energy production-related processes, and it's more appropriate to explain HOKE's use of magnesium glycinate in the context of energy homeostasis and daily nutritional support.

How should HOKE's formula be promoted?

"NAD+ precursor support, energy metabolism support, antioxidant nutritional support, daily health management for adults," etc.